Jin Uses Multiple Approaches to Study Biological Systems
Xiangshu Jin recently joined Michigan State University as assistant professor, in the Department of Biochemistry and Molecular Biology, in the College of Natural Science. Jin, who was recruited as part of the university’s Global Impact Initiative, takes a multidisciplinary approach to understanding the molecular underpinnings of biological systems and pathways at multiple levels. She combines structural biology (x-ray crystallography, electron microscopy), biochemistry, biophysics (analytical ultracentrifugation, isothermal titration calorimetry, surface plasmon resonance, etc.), chemical biology, cell biology, and computational methods to investigate the mechanisms that underlie fundamental biological processes at atomic, molecular, cellular, and systems levels.
PhD: Michigan State University
Recent Professional Activities: Postdoctoral Research Fellow, 2003-06, Harvard University
Most Recent Publication: Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers, Jin, X.; Walker, M.A.; Felsovalyi, K.; Vendome, J.; Bahna, F.; Mannepalli, S.; Cosmanescu, F.; Ahlsen, G.; Honig, B.; Shaprio, L., Proc. Natl. Acad. Sci. U.S.A. 2012, 109(3), E127-134.
About My Research: “Our current research efforts are mainly directed towards the following areas: the molecular basis of cell-cell communication in development, structural basis for molecular interactions regulating autophagy (dysregulation of autophagy is implicated in many pathological situations such as cancer, diabetes, and neurodegenerative diseases), and the structural basis for molecular interactions regulating necrotic cell death.”