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Mass Spec/Proteomics Researcher Joins MSU

Liangliang Sun

Liangliang Sun recently joined MSU as an assistant professor in the Department of Chemistry. The focus of his research is on the development of highly sensitive, high throughput and high-resolution proteomic techniques for understanding how proteins/protein complexes modulate early embryogenesis at high time resolution and at single cell resolution. Sun’s appointment is part of the Global Impact Initiative.

Prior to joining MSU, Sun was a research assistant professor (2013-16) and a postdoctoral fellow (2011-12) at the University of Notre Dame.

Research Interests: The Sun group aims to develop highly sensitive, high throughput and high-resolution proteomic techniques based on capillary zone electrophoresis-mass spectrometry (CZE-MS). Those techniques enable high time and spatial-resolution characterization of proteome dynamics in cells during various biological processes. His group collaborates with developmental biologists and apply those techniques for understanding how proteins, post-translational modifications (PTMs) of proteins, and protein complexes modulate early embryogenesis.

Ph.D.: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, analytical chemistry (2011)

Recent Honors:

  • Session chair of “NEW NANO-SCALE AND MICROFLUIDIC SEPARATIONS AND MS” at the 63rd ASMS Conference on Mass Spectrometry and Allied Topics (2015, USA)
  • Young Investigator Travel Award of HUPO 2009 World Congress (2009, Canada)
  • The DICP-Corning Award (2009)

Publications and Papers:

Sun has 74 peer-reviewed publications (h-index: 25). Full list of publications: https://www.ncbi.nlm.nih.gov/sites/myncbi/1F_bvj6iQhQ5i/bibliography/48984928/public/?sort=date&direction=ascending. Selected publications are listed.

Chen D, Shen X, Sun L (Corresponding author). Capillary zone electrophoresis-mass spectrometry with microliter-scale loading capacity, 140 min separation window and high peak capacity for bottom-up proteomics. Analyst 2017, 142(12):2118-2127.

Sun L, Dubiak KM, Peuchen EH, Zhang Z, Zhu G, Huber PW, Dovichi NJ. Single Cell Proteomics Using Frog (Xenopus laevis) Blastomeres Isolated from Early Stage Embryos, Which Form a Geometric Progression in Protein Content. Anal Chem. 2016, 88(13):6653-7.

Sun L, Bertke MM, Champion MM, Zhu G, Huber PW, Dovichi NJ. Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development. Sci Rep. 2014 Mar 14;4:4365.

Sun L, Zhu G, Zhang Z, Mou S, Dovichi NJ. Third-generation electrokinetically pumped sheath-flow nanospray interface with improved stability and sensitivity for automated capillary zone electrophoresis-mass spectrometry analysis of complex proteome digests. J Proteome Res. 2015, 14(5):2312-21.

Sun L, Hebert AS, Yan X, Zhao Y, Westphall MS, Rush MJ, Zhu G, Champion MM, Coon JJ, Dovichi NJ. Over 10,000 peptide identifications from the HeLa proteome by using single-shot capillary zone electrophoresis combined with tandem mass spectrometry. Angew Chem Int Ed. 2014, 53(50):13931-3.

Contact: lsun@chemistry.msu.edu

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