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Michigan State University Office of Research and Innovation

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2018-10-25
Oct
25
2018

Dr. Arnett, Former AHA President Visits MSU

3:30 p.m.
FEE HALL, E4 Directions to event location

Arnett

Donna Arnett, PhD, MSPH 

Dean and Professor, College of Public Health
University of Kentucky, Lexington
Past President, American Heart Association

"HyperGEN—Genetics of Left Ventricular Hypertrophy: Omic approaches to understanding echocardiographic traits"

Left ventricular (LV) mass and related echocardiographic phenotypes are heritable, and they are important predictors of cardiovascular disease, particularly in hypertensive individuals. The HyperGEN: Genetics of Left Ventricular Hypertrophy (LVH) Study has been using cutting-edge omic approaches in a cohort of hypertensive sibships to discover the genetic, genomic, and epigenomic correlates of these traits since 1995. As such, HyperGEN: LVH serves as excellent case study to illustrate evolving genetic epidemiological methods and the power, limitations, and challenges of these methods. We will trace the history of HyperGEN: LVH through the eras of linkage and candidate gene analysis, genome-wide association studies, whole-exome sequencing studies, and epigenome-wide association studies into the current era of whole-genome sequencing. The use of animal and cellular models, gene expression analysis, and pathway analysis in conjunction with association studies will also be discussed. 

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