Inside the diseased cell, the genes are in chaos. Some are receiving signals to overproduce a protein. Others are reducing activity to abnormal levels. Up is down and down is up.
The right molecule could restore order, reversing dysregulation in specific genes. But finding the ideal compound could require examining millions of chemicals for their influence on hundreds or thousands of genes.
An MSU-led team of researchers has demonstrated a better way. Using machine learning trained on enormous amounts of published data, they were able to predict how chemicals will influence gene expression, based solely on the structure of the chemical.
Their study, recently published in the journal Cell, discovered compounds that are promising for treatment of two difficult diseases: the most aggressive form of liver cancer and a chronic lung disease with no curative options.